TLR3/IFNB Leeporter(TM) Luciferase Reporter-HEK293 Cell Line Preis auf Anfrage

Produktübersicht

• Artikelname: TLR3/IFNB Leeporter(TM) Luciferase Reporter-HEK293 Cell Line Preis auf Anfrage
• Artikelnummer: ABI-14-122ACL
• Hersteller Artikelnummer: 14-122ACL
• Alternativnummer: ABI-14-122ACL-1VIAL
• Hersteller: Abeomics
• Kategorie: Zellen/Zellkultur
• Applikation: FA

Produktbeschreibung

The TLR3/IFNB Leeporter(TM) Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses full-length human Toll-like receptor 3 (TLR3) and Renilla luciferase reporter gene under the transcriptional control of the human IFN-beta (IFNB) promoter. Functional activity of the cell line has been validated by TLR3 ligand assay (Figure 1), in which upon activation by poly (I:C), TLR3 quickly initiates TRIF-dependent signaling pathway and mediates nuclear translocation of IRF3 that induces IFNB promoter activity.The TLR3/IFNB activation by poly(I:C) is shown in Figure 1.

Anwendungsbeschreibung

• Application Verdünnung: Application: Monitor the TLR3 signaling pathway activity. Screen for activators or inhibitors of the TLR3 signaling pathway. Culture conditions: Cells should be grown at 37C with 5% CO2 using DMEM medium (w/ L-Glutamine, 4.5g/L Glucose and Sodium Pyruvate