CD27/NF-kB Leeportera Luciferase Reporter-Jurkat Cell Line Preis auf Anfrage

Produktübersicht

• Artikelname: CD27/NF-kB Leeportera Luciferase Reporter-Jurkat Cell Line Preis auf Anfrage
• Artikelnummer: ABI-14-151ACL
• Hersteller Artikelnummer: 14-151ACL
• Alternativnummer: ABI-14-151ACL-1VIAL
• Hersteller: Abeomics
• Kategorie: Zellen/Zellkultur
• Applikation: FA

Produktbeschreibung

The CD27/NF-kB Leeportera Luciferase Reporter cell line is a stably transfected Jurkat cell line which expresses full-length human CD27 along with the Renilla luciferase reporter gene under the transcriptional control of the NF-kB response element. CD27 is a tumor necrosis factor (TNF) receptor superfamily member found on T cells, B cells and NK cells. It binds to its ligand, CD70, which is present on activated lymphocytes and dendritic cells, triggering a co-stimulatory signal that facilitates T cell activation, survival and proliferation. Targeting the CD27/CD70 pathway has emerged as a promising therapeutic approach for treating both innate and adaptive immune disorders, as well as cancer.

Anwendungsbeschreibung

• Application Verdünnung: Application: Monitor the T cell co-stimulatory signaling pathway activity. Screen for activators or inhibitors of the CD27/CD70 signaling pathway. Culture conditions: Cells should be grown at 37oC with 5% CO2 using RPMI medium supplemented with 10% heat-i