Anti-SARS-CoV-2 Spike Protein S1, mAb (Rec,blocking) (Clone: Covi-1) (Azide free), Clone: [Covi-1], Monoclonal

Produktübersicht

• Artikelname: Anti-SARS-CoV-2 Spike Protein S1, mAb (Rec,blocking) (Clone: Covi-1) (Azide free), Clone: [Covi-1], Monoclonal
• Artikelnummer: ABI-29-1009
• Hersteller Artikelnummer: 29-1009
• Alternativnummer: ABI-29-1009-100UG
• Hersteller: Abeomics
• Kategorie: Antikörper
• Applikation: ELISA, FA, WB
• Immunogen: Recombinant SARS-CoV-2 Spike Protein S1 receptor binding domain.
• Alternative Synonym: 2019-nCoV Spike Protein S1

Produktbeschreibung

This is a Recombinant Human antibody Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many other wild animals. Recently, a new severe acute respiratory syndrome i-coronavirus called SARS-CoV-2 (or 2019-nCoV) has emerged, which causes an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19). SARS-CoV-2 shares 79.5% sequence identity with SARS-CoV and is 96.2% identical at the genome level to the bat coronavirus BatCoV RaTG133, suggesting it had originated in bats. SARS-CoV-2 contains 4 structural proteins, including Envelope (E), Membrane (M), Nucleocapsid (N) and Spike (S), which is a transmembrane protein, composed of two subunits S1 and S2. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor Angiotensin-Converting Enzyme 2 (ACE2) present at the surface of epithelial cells, causing mainly infection of human respiratory cells.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [Covi-1]
• UniProt: P0DTC2
• Reinheit: >=98% (SDS-PAGE)
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: ELISA Binding Assay, Functional Application: Blocking, Western Blot: Works only in non-denatured conditions (1:1000). Recognizes and binds to recombinant SARS-CoV-2 Spike Protein S1. It blocks the interaction of SARS-CoV-2 Spike Protein S1 (RBD) to human

Bilder

Figure 1: Binding of human ACE2 to the Spike protein of SARS-CoV-2 is inhibited by the antibody SARS-CoV-2 Spike Protein S1, mAb (rec.) (blocking) (Clone: Covi-1).

Figure 2: ELISA binding assay with SARS-CoV-2 S1 Protein (RBD) (rec.) (His) using anti-SARS-CoV-2 Spike Protein S1, mAb (rec.) (Clone: Covi-1) (blue line) and an unrelated antibody as negative control (red line)