Molecular Characterization: IL2(Ala21-Thr153) mFc(Pro99-Lys330)Molecular weight: The protein has a predicted molecular mass of 41.5 kDa after removal of the signal peptide.The apparent molecular mass of IL2-mFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant Human IL2 with C-terminal mouse Fc tagThis gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
