Molecular Characterization: HPSE(Gln36-Ile543)6A-His tagMolecular weight: The protein has a predicted molecular mass of 58.4 kDa after removal of the signal peptide. The apparent molecular mass of HPSE-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant human HPSE protein with C-terminal6A-His tagHeparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
