Recombinant Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag
Artikelnummer:
ABI-32-17842
Hersteller Artikelnummer:
32-17842
Alternativnummer:
ABI-32-17842-50UG
Hersteller:
Abeomics
Wirt:
Human
Kategorie:
Proteine/Peptide
Alternative Synonym:
Integrin alpha 2 beta 1,ITGA2 & ITGB1
Molecular Characterization: ITGA2(Tyr30-Thr1132)6A-His tag and ITGB1(Gln21-Asp728) hFc(Glu99-Ala330)Molecular weight: The heterodimer protein has a predicted molecular mass of 121.8 kDa and 104.5 kDa separately after removal of the signal peptide.Description: Recombinant human ITGA2 protein with C-terminal6A-His tag and human ITGB1 protein with C-terminal human Fc tagIntegrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2: ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
