Molecular Characterization: ADAM28(Ile19-His664)6A-His tagMolecular weight: The protein has a predicted molecular mass of 73.7 kDa after removal of the signal peptide. The apparent molecular mass of ADAM28-His is approximately 55-70 kDa and 70-100 kDa due to glycosylation.Description: Recombinant human ADAM28 protein with C-terminal6A-His tagThis gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants.
