Molecular Characterization: Mesothelin(37-286)(Leu37-Arg286)6A-His tagMolecular weight: The protein has a predicted molecular mass of 27.6 kDa after removal of the signal peptide. The apparent molecular mass of Mesothelin(37-286)-His is approximately 25-35 kDa due to glycosylation.Description: Recombinant human Mesothelin(37-286) protein with C-terminal6A-His tagThis gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
