Molecular Characterization: RAGE?Thr27-Thr340?+6Afa€His tag Molecular Weight: The protein has a predicted molecular mass of 34.2 kDa after removal of the signal peptide. The apparent molecular mass of RAGE-His is approximately 35-55 kDa due to glycosylation. Description: Recombinant human RAGE protein with C-terminal6A-His tag The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
