Molecular Characterization: PROKR1(Met1-Lys62) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 33.1 kDa after removal of the signal peptide. The apparent molecular mass of PROKR1-hFc is approximately 35-70 kDa due to glycosylation.Description: Recombinant Human PROKR1 Protein with C-terminal human Fc tagThis gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage.
