Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)

Produktübersicht

• Artikelname: Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)
• Artikelnummer: ABI-32-7352-10
• Hersteller Artikelnummer: 32-7352-10
• Alternativnummer: ABI-32-7352-10-10UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide

Produktbeschreibung

Source: Human Cells. MW :23.98kD. Recombinant Human SLAMF6 is produced by our Mammalian expression system and the target gene encoding Leu28-Lys225 is expressed with a 6His tag at the C-terminus. SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN- gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

Produkteigenschaften

• NCBI: 114836
• UniProt: Q96DU3
• Antibody Type: Recombinant Antibody

Anwendungsbeschreibung

• Application Verdünnung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freez