Recombinant Human Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc)

Produktübersicht

• Artikelname: Recombinant Human Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc)
• Artikelnummer: ABI-32-8211
• Hersteller Artikelnummer: 32-8211
• Alternativnummer: ABI-32-8211-50UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide

Produktbeschreibung

Source: Human Cells. MW :61.7kD. Recombinant Human Death Receptor 6 is produced by our Mammalian expression system and the target gene encoding Gln42-Leu350 is expressed with a Fc tag at the C-terminus. Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-a.

Produkteigenschaften

• NCBI: 27242
• UniProt: O75509
• Antibody Type: Recombinant Antibody

Anwendungsbeschreibung

• Application Verdünnung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freez