Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

Produktübersicht

• Artikelname: Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)
• Artikelnummer: ABI-32-9385-500
• Hersteller Artikelnummer: 32-9385-500
• Alternativnummer: ABI-32-9385-500-500UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Cytotoxic and Regulatory T-Cell Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, CD355, CRTAM

Produktbeschreibung

Source : Human Cells,Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNgamma or IL-22 production.

Produkteigenschaften

• Antibody Type: Recombinant Antibody