Recombinant Human Interleukin-4 Receptor Subunit Alpha/IL-4 Ralpha(C-mFc)

Produktübersicht

• Artikelname: Recombinant Human Interleukin-4 Receptor Subunit Alpha/IL-4 Ralpha(C-mFc)
• Artikelnummer: ABI-32-9387
• Hersteller Artikelnummer: 32-9387
• Alternativnummer: ABI-32-9387-50UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, CD124, IL-4-binding protein, IL4-BP, IL4R, IL4RA

Produktbeschreibung

Source : Human Cells,Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra, generated by alternate splicing or proteolysis, retain ligand binding properties and inhibit IL-4 bioactivity. IL4-Ra is a component of two distinct receptor complexes and shows species selectivity between human and mouse.

Produkteigenschaften

• Antibody Type: Recombinant Antibody