Recombinant Human Receptor-Type Tyrosine-Protein Kinase FLT3/FLT3 (C-Fc)

Produktübersicht

• Artikelname: Recombinant Human Receptor-Type Tyrosine-Protein Kinase FLT3/FLT3 (C-Fc)
• Artikelnummer: ABI-32-9398-500
• Hersteller Artikelnummer: 32-9398-500
• Alternativnummer: ABI-32-9398-500-500UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Receptor-Type Tyrosine-Protein Kinase FLT3, FL Cytokine Receptor, Fetal Liver Kinase-2, FLK-2, Fms-Like Tyrosine Kinase 3, FLT-3, Stem Cell Tyrosine Kinase 1, STK-1, CD135, FLT3, FLK2, STK1

Produktbeschreibung

Source : Human Cells,The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2and Stk-1is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain. Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin. Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations. The ligand for Flt-3 (FL) has been identified to be a transmembrane protein with structural homology to M-CSF and SCF. Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist.

Produkteigenschaften

• Antibody Type: Recombinant Antibody