Recombinant Rat Tumor Necrosis Factor/TNF-alpha

Produktübersicht

• Artikelname: Recombinant Rat Tumor Necrosis Factor/TNF-alpha
• Artikelnummer: ABI-32-9537
• Hersteller Artikelnummer: 32-9537
• Alternativnummer: ABI-32-9537-50UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Tumor Necrosis Factor, Cachectin, TNF-Alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Tumor Necrosis Factor, Membrane Form, Tumor Necrosis Factor, Soluble Form, Tnf, Tnfa, Tnfsf2

Produktbeschreibung

Source : E. coli,Tumor necrosis factor alpha (TNF-alpha, TNFSF2) is the prototypic ligand of the TNF superfamily. Rat TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 179 aa extracellular domain (ECD). Within the ECD, rat TNF-alpha shares 94% aa sequence identity with mouse. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.

Produkteigenschaften

• Antibody Type: Recombinant Antibody