Recombinant Human Cell Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-His, variant)

Produktübersicht

• Artikelname: Recombinant Human Cell Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-His, variant)
• Artikelnummer: ABI-32-9620
• Hersteller Artikelnummer: 32-9620
• Alternativnummer: ABI-32-9620-50UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274,Skin cancer, gastric cancer, liver cancer, Urothelial cancer, Lung cancer, melanoma, non-small cell lung cancer, NSCLC, cancer, tumor

Produktbeschreibung

Source : Human Cells, CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Produkteigenschaften

• Antibody Type: Recombinant Antibody