Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)

Produktübersicht

• Artikelname: Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)
• Artikelnummer: ABI-32-9725-500
• Hersteller Artikelnummer: 32-9725-500
• Alternativnummer: ABI-32-9725-500-500UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Tumor necrosis factor receptor superfamily member 21,Death receptor 6,Tnfrsf21,CD358,BM-018,DR6

Produktbeschreibung

Source : Human Cells,Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Produkteigenschaften

• Antibody Type: Recombinant Antibody