Recombinant Human NGAL/Lipocalin-2/LCN2 (C-6His, Human Cells)

Produktübersicht

• Artikelname: Recombinant Human NGAL/Lipocalin-2/LCN2 (C-6His, Human Cells)
• Artikelnummer: ABI-32-9740-50
• Hersteller Artikelnummer: 32-9740-50
• Alternativnummer: ABI-32-9740-50-50UG
• Hersteller: Abeomics
• Kategorie: Proteine/Peptide
• Alternative Synonym: Neutrophil gelatinase-associated lipocalin, NGAL, 25 kDa alpha-2-microglobulin-relatedsubunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2,p25,HNL,NGAL

Produktbeschreibung

Source : Human Cells,LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Produkteigenschaften

• Antibody Type: Recombinant Antibody