Polyclonal Antibody to Akt (Phospho-Thr308), Rabbit
Artikelnummer:
ABI-35-1054-50
Hersteller Artikelnummer:
35-1054-50
Alternativnummer:
ABI-35-1054-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of threonine 308 (M-K-T(p)-F-C) derived from Human Akt.
Alternative Synonym:
C-AKT|| PKB|| PKB-alpha|| RAC|| RAC-PK-alpha
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Tremblay F, et al. (2005)Diabetes, 54(9): 2674-84. Xu BE, et al. (2005)J Biol Chem, 280(40): 34218-23. Samuels Y, et al. (2005)Cancer Cell, 7(6): 561-73. Di Maira G, et al. (2005)Cell Death Differ, 12(6): 668-77.
