Polyclonal Antibody to p53 (Phospho-Ser33), Rabbit
Artikelnummer:
ABI-35-1094-50
Hersteller Artikelnummer:
35-1094-50
Alternativnummer:
ABI-35-1094-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human
Immunogen:
Peptide sequence around phosphorylation site of serine 33 (V-L-S(p)-P-L) derived from Human p53.
Alternative Synonym:
P53||BCC7||LFS1||TRP53
Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Lin T, et al. (2005) Nat Cell Biol, 7(2): 165-71. Vega FM, et al. (2004) Mol Cell Biol, 24(23): 10366-80. Li J, et al. (2004) J Biol Chem, 279(40): 41275-9. Wang J, et al. (2004) J Biol Chem, 279(38): 39584-92.
