Polyclonal Antibody to Paxillin (Phospho-Tyr31), Rabbit
Artikelnummer:
ABI-35-1188
Hersteller Artikelnummer:
35-1188
Alternativnummer:
ABI-35-1188-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 31 (T-P-Y(p)-S-Y) derived from Human Paxillin.
Alternative Synonym:
Paxillin, Pxn
An antiphosphotyrosine antibody was used to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and a 76-kD protein was obtained that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells (Ref.1). This protein was purified from chicken gizzard smooth muscle, and was named Pxn (Paxillin) (paxillus means small stake or peg in Latin) as a protein tethered to the membrane at focal adhesions Davidson D, et al. (2001) EMBO J 20(13): 3414-3426. Fleming I, et al. (1999) Proc Natl Acad Sci U S A 96(3): 1123-1128. Goldberg MB. (2001) Microbiol Mol Biol Rev 65(4): 595-626. Kook S, et al. (2000) Mol Biol Cell 11(3): 929-939.
