Polyclonal Antibody to SP1 (Phospho-Thr739), Rabbit
Artikelnummer:
ABI-35-1224-50
Hersteller Artikelnummer:
35-1224-50
Alternativnummer:
ABI-35-1224-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of threonine 739 (T-A-T(p)-P-S) derived from human SP1
Alternative Synonym:
TSFP1|| Sp1 transcription factor
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-a G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
