Polyclonal Antibody to P38 MAPK (Phospho-Thr180), Rabbit
Artikelnummer:
ABI-35-1233
Hersteller Artikelnummer:
35-1233
Alternativnummer:
ABI-35-1233-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ) derived from Human P38MAPK.
Alternative Synonym:
MAPK2|| MAPKAPK-2|| MAPKAPK2
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis. Kim JE, et al. (2005) J Proteome Res Jul-Aug, 4(4): 1339-1346 Meng F, et al. (2005) Am J Physiol Cell Physiol May 25 Jin ZH, et al. (2005)Oncogene Mar 17, 24(12): 1973-1981
