Polyclonal Antibody to Cortactin (Phospho-Tyr466), Rabbit
Artikelnummer:
ABI-35-1250-50
Hersteller Artikelnummer:
35-1250-50
Alternativnummer:
ABI-35-1250-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.
Alternative Synonym:
Amplaxin|| CTTN|| EMS1|| SRC8
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C, et al. (2006) J Biol Chem , 281(40):30081-30093 Head JA, et al. (2003) Mol Biol Cell ,14(8):3216-3229 Li Y, et al. (2000) J Biol Chem , 275(47): 37187-37193 Kinley AW, et al. (2003) Curr Biol , 13(5): 384-393
