Polyclonal Antibody to TrkA (Phospho-Ser791), Rabbit
Artikelnummer:
ABI-35-1293
Hersteller Artikelnummer:
35-1293
Alternativnummer:
ABI-35-1293-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA.
Alternative Synonym:
High affinity nerve growth factor receptor precursor|| NTRK1|| Slow nerve growth factor receptor|| TRK|| TRK1 transforming tyrosine kinase protein
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
