Polyclonal Antibody to PKM2(phospho-Ser37), Rabbit
Artikelnummer:
ABI-35-1300-50
Hersteller Artikelnummer:
35-1300-50
Alternativnummer:
ABI-35-1300-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human
Immunogen:
Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.
Alternative Synonym:
PKM||PK3||OIP3||PK2
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Weiwei Yang1, Yanhua Zheng1, Yan Xia1, Haitao Ji, ERK1/2-dependent phosphorylation and nucleartranslocation of PKM2 promotes the Warburg effect. Nature Cell Biology(2012)|doi:10.1038/ncb2629
