Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Klonalität:
Monoclonal
Reinheit:
Protein A
Application Verdünnung:
WB 1:1000-1:5000, Validated Applications:WB,ELISA,IHC-P,FCM,ICC/IF,IP Specificity: 2019-nCoV CoV Nucleocapsid Has cross-reactivity in ELISA and WB with SARS-CoV Nucleoprotein / NP Protein .
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