Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody(Clone: TYRP1/3284), Clone: [TYRP1/3284], Mouse

Produktübersicht

• Artikelname: Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody(Clone: TYRP1/3284), Clone: [TYRP1/3284], Mouse
• Artikelnummer: ABI-36-3332-20
• Hersteller Artikelnummer: 36-3332-20
• Alternativnummer: ABI-36-3332-20-20UG
• Hersteller: Abeomics
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: ELISA, IHC
• Spezies Reaktivität: Human
• Immunogen: A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)
• Alternative Synonym: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

Produktbeschreibung

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence sµggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [TYRP1/3284]
• NCBI: 7306
• UniProt: P17643

Anwendungsbeschreibung

• Application Verdünnung: ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95