Anti-Cyclin E (G1/S-Phase Cyclin) Monoclonal Antibody(Clone: CCNE1/2587), Clone: [CCNE1/2587], Mouse
Artikelnummer:
ABI-36-3449-20
Hersteller Artikelnummer:
36-3449-20
Alternativnummer:
ABI-36-3449-20-20UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
ELISA
Spezies Reaktivität:
Human
Immunogen:
Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176) (exact sequence is proprietary)
Alternative Synonym:
CCNE1, Cyclin E1, G1/S-specific cyclin-E1
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress throµgh S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
