Anti-GITR / Tnfrsf18 (Mouse) Monoclonal Antibody(Clone: DTA-1), Clone: [DTA-1], Rat
Artikelnummer:
ABI-36-3688
Hersteller Artikelnummer:
36-3688
Alternativnummer:
ABI-36-3688-100UG
Hersteller:
Abeomics
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FACS, IF
Spezies Reaktivität:
Mouse
Immunogen:
Mouse CD25+ CD4+ T cells
Alternative Synonym:
Activation-inducible TNF-alphaelated ligand, AITRL, GITRL, Glucocorticoid induced TNFR related protein ligand, Glucocorticoid-induced TNF-alphaelated ligand, hGITRL, TL6, TNFSF18, Tumor necrosis factor (ligand) superfamily member 18
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-alphaeceptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to aµgment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
