Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
Alternative Synonym:
HPV16 regulatory protein E2, Human papilloma virus 16 E2, Human papilloma virus 16 regulatory protein E2, Human papillomavirus type 16 E2, Human papillomavirus type 16 regulatory protein E2, Regulatory protein E2
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first throµgh the binding of p53 and the second throµgh the binding of the viral genome.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[TVG 261]
Antibody Type:
Monoclonal Antibody
Application Verdünnung:
Western Blot (1-2ug/ml),
Fig. 1: SDS-PAGE Analysis Purified Mouse Monoclonal Antibody HPV16 E2 (Human Papilloma Virus 16). Confirmation of Purity and Integrity of Antibody.
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