Anti-Cytokeratin, pan (Epithelial Marker) Polyclonal Antibody, Rabbit
Artikelnummer:
ABI-36-3814-20
Hersteller Artikelnummer:
36-3814-20
Alternativnummer:
ABI-36-3814-20-20UG
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FACS, IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human KRT76 and KRT77 proteins
Alternative Synonym:
K1B, KRT1B, Keratin, type II cytoskeletal 1b, K77, CK-1B, Keratin 1B, Keratin-77, Cytokeratin-1B, Type-II Keratin Kb39
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1), 64kDa (CK3), 59kDa (CK4), 58kDa (CK5), 56kDa (CK6), 52kDa (CK8), 56.5kDa (CK10), 50kDa (CK14), 50kDa (CK15), 48kDa (CK16), 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. It is a broad spectrum anti pan-cytokeratin antibody, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It may be useful to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has high sensitivity in the recognition of epithelial cells and carcinomas.
Klonalität:
Polyclonal
Application Verdünnung:
Flow Cytometry (0.5-1ug/million cells), ,Immunofluorescence (1-2ug/ml), Western Blotting (0.5-1ug/ml for 2 hours at RT), ,Immunohistology (Formalin-fixed) (0.25-0.5ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue section
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