Anti-CD137, Mouse Monoclonal Antibody(Clone: LOB12), Clone: [LOB12], Rat
Artikelnummer:
ABI-36-3824-20
Hersteller Artikelnummer:
36-3824-20
Alternativnummer:
ABI-36-3824-20-20UG
Hersteller:
Abeomics
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FA, FACS, IF
Spezies Reaktivität:
Mouse
Immunogen:
Murine CD137 human Fc fusion protein
Alternative Synonym:
4-1BB ligand receptor, 4-1BB, Mouse, homolog, CD137, HLDA VI, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of Mouse Ly63, Ly63, Mouse, Receptor protein 4 1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNF receptor superfamily member 9, Tu
CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.
