Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Mapt, Mtapt, Tau
The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau are composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles(NFTs) characteristic of Alzheimers brain. Microtubule-associated protein tau(MTBT1) is mapped to chromosome 17q21.
Western blot : 0.5-1µg/ml, Immunohistochemistry(Paraffin-embedded Section) : 1-2µg/ml
Figure 1: Anti-Tau antibody(monoclonal) 39-1093. Western blotting: Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate, Lane 3: Mouse Brain Tissue Lysate, Lane 4: Mouse Brain Tissue Lysate.
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