Human Activin RIIB / ACVR2B Protein, His Tag (MALS & SPR verified), Unconjugated
Artikelnummer:
ABS-ACB-H5226-200UG
Hersteller Artikelnummer:
ACB-H5226-200ug
Alternativnummer:
ABS-ACB-H5226-200UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Activin receptor type2B (ACVR2B) is also known as ActRIIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factorbeta (TGFbeta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligandbinding extracellular domain with cysteinerich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3 to 4fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4). - Proteine/Peptide
Immobilized Human Activin RIIB, His Tag (Cat. No. ACB-H5226) at 1 µg/mL (100 µL/well) can bind Bimagrumab with a linear range of 0.05-2 ng/mL (Routinely tested).
Human Activin RIIB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
ACB-H5226-200ug
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