Human ADORA2A Protein, Flag,His Tag (Detergent), Unconjugated
Artikelnummer:
ABS-ADA-H52D3-100UG
Hersteller Artikelnummer:
ADA-H52D3-100ug
Alternativnummer:
ABS-ADA-H52D3-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
This gene encodes a member of the guanine nucleotidebinding protein (G protein)coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are sevenpass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A readthrough transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiledcoil domains 1like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be noncoding. - Proteine/Peptide
