Cynomolgus B7-H6 / NCR3LG1 Protein, His Tag, Unconjugated, Human
Artikelnummer:
ABS-B76-C52HA-100UG
Hersteller Artikelnummer:
B76-C52Ha-100ug
Alternativnummer:
ABS-B76-C52HA-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Unconjugated
The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene, however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) Tcell therapies have demonstrated durable and potentially curative therapeutic efficacy against Bcell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. - Proteine/Peptide
