Rhesus macaque CCR8 Full Length Protein (VLP), Unconjugated, Human
Artikelnummer:
ABS-CC8-R52P3-20UG
Hersteller Artikelnummer:
CC8-R52P3-20ug
Alternativnummer:
ABS-CC8-R52P3-20UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Unconjugated
CCR8 is a key chemokine receptor primarily expressed on regulatory T cells (Tregs) infiltrating the tumor microenvironment. It plays a decisive role in mediating immunosuppression by facilitating Treg recruitment and activation. Emerging research highlights the interaction between CCR8 and glycosaminoglycans (GAGs), which serve as essential coreceptors. GAGs facilitate the presentation of ligands like CCL1 to CCR8, effectively concentrating chemokines on the cell surface to enhance signaling efficiency. Targeting the CCR8GAG axis represents a sophisticated strategy for selective Treg depletion, offering high precision for cancer immunotherapy while minimizing systemic autoimmune side effects. - Proteine/Peptide
