Human CD40 / TNFRSF5 Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human CD40 / TNFRSF5 Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-CD0-H5253-1MG
• Hersteller Artikelnummer: CD0-H5253-1mg
• Alternativnummer: ABS-CD0-H5253-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembranespanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T celldependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteinerich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyperIgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibodyspecific immune response, and a lack of germinal center formation. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 45.3 kDa
• Tag: C-Fc
• NCBI: 25942
• Puffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: CD40

Bilder

Immobilized Human CD40 Ligand, His,Flag Tag, premium grade (Cat. No. CDL-H52Db) at 5 µg/mL (100 µL/well) can bind Human CD40, Fc Tag (HPLC-verified) (Cat. No. CD0-H5253) with a linear range of 0.02-0.156 µg/mL (Routinely tested).

CD0-H5253-1mg

Human CD40 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.