Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag, Unconjugated
Artikelnummer:
ABS-CD0-H5257-1MG
Hersteller Artikelnummer:
CD0-H5257-1mg
Alternativnummer:
ABS-CD0-H5257-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Cluster of Differentiation 100 (CD100) is also known as Semaphorin4D (SEMA4D), is a singlepass type I membrane protein which belongs to the semaphorin family, and is a human 150kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membranebound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an RRas GTPaseactivating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury. - Proteine/Peptide
Immobilized Human Plexin B2, His Tag (Cat. No. PL2-H52H3) at 5 µg/mL (100 µL/well) can bind Human SEMA4D, Fc Tag (Cat. No. CD0-H5257) with a linear range of 0.039-1.25 µg/mL (Routinely tested).
Human SEMA4D, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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