Human CD20 / MS4A1 Full Length Protein, His Tag (Detergent) (SPR verified), Unconjugated
Artikelnummer:
ABS-CD0-H52H3-20UG
Hersteller Artikelnummer:
CD0-H52H3-20ug
Alternativnummer:
ABS-CD0-H52H3-20UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Blymphocyte antigen CD20 is also known as Blymphocyte surface antigen B1, Leukocyte surface antigen Leu16, Membranespanning 4domains subfamily A member 1 and MS4A1, is an activatedglycosylated phosphoprotein expressed on the surface of all Bcells beginning at the proB phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last, it is present from late proB cells through memory cells, but not on either early proB cells or plasma blasts and plasma cells. It is found on Bcell lymphomas, hairy cell leukemia, Bcell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal Bcell immune response, specifically against Tindependent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5), also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. - Proteine/Peptide
