Human Siglec-3 / CD33 (140-232) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human Siglec-3 / CD33 (140-232) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified), Unconjugated
• Artikelnummer: ABS-CD3-H5258-100UG
• Hersteller Artikelnummer: CD3-H5258-100ug
• Alternativnummer: ABS-CD3-H5258-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a singlepass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Iglike lectin) family. Human CD33 / Siglec3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an Nterminal Iglike Vtype domain, one Iglike C2type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec3 usually considered myeloidspecific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec3 induces apoptosis in acute myeloid leukemia. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 37.8 kDa
• Tag: C-LlamaFc(LlamaIgG2b)
• NCBI: 20138
• Puffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: Siglec-3

Bilder

Human Siglec-3 (140-232), Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.