Human CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-CD7-H525B-100UG
• Hersteller Artikelnummer: CD7-H525b-100ug
• Alternativnummer: ABS-CD7-H525B-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

cKIT activation has been shown to have oncogenic activity in gastrointestinal stromal tumors (GISTs), melanomas, lung cancer, and other tumor types. The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in latestage trials in melanoma and GIST. KIT overactivity can be the result of many genomic events from genomic amplification to overexpression to missense mutations. Missense mutations have been shown to be key players in mediating clinical response and acquired resistance in patients being treated with these targeted therapeutics. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 50.2 kDa
• Tag: C-Fc
• NCBI: 10721
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: CD117

Bilder

Human CD117 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.