Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. CD8A forms disulfidelinked heterodimers with CD8B at the cell surface. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 Tcells. Additionally, CD8B plays a critical role in thymic selection of CD8+ Tcells. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. - Proteine/Peptide
Immobilized Human Anti-CD8 alpha Antibody, Human IgG1 at 1 µg/mL (100 µL/well) can bind Biotinylated Cynomolgus CD8A&CD8B Heterodimer Protein, His,Avitag&Tag Free (Cat. No. CDA-C82W3) with a linear range of 0.002-0.063 µg/mL (QC tested).
Biotinylated Cynomolgus CD8A&CD8B Heterodimer Protein, His,Avitag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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