Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin, Unconjugated
Artikelnummer:
ABS-CDL-H525A-100UG
Hersteller Artikelnummer:
CDL-H525a-100ug
Alternativnummer:
ABS-CDL-H525A-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated Tand Blymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of Tcells, and thus is invloved in the biological processes including Tcell activation, the proliferation of costimulated Tcells, as well as the generation of cytolytic Tcells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNgamma production, on NK cells. - Proteine/Peptide
