Mouse CD40 Ligand / TNFRSF5 Protein, His,Flag Tag, active trimer (MALS verified), Unconjugated, Human

Produktübersicht

• Artikelname: Mouse CD40 Ligand / TNFRSF5 Protein, His,Flag Tag, active trimer (MALS verified), Unconjugated, Human
• Artikelnummer: ABS-CDL-M52D5-1MG
• Hersteller Artikelnummer: CDL-M52D5-1mg
• Alternativnummer: ABS-CDL-M52D5-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Mouse
• Konjugation: Unconjugated

Produktbeschreibung

CD40 ligand is also known as CD40L, CD154, TNFSF5 and Tcell antigen Gp39, is a singlepass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as nonhaematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members. CD40 ligand binds to CD40 on antigenpresenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 50.5 kDa
• Tag: N-6*His & N-Flag
• NCBI: 27548
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: CD40 Ligand

Bilder

Immobilized Mouse CD40 Ligand, His,Flag Tag (Cat. No. CDL-M52D5) at 2 µg/mL (100 µL/well) can bind Mouse CD40, Fc Tag (Cat. No. TN5-M5259) with a linear range of 1-32 ng/mL (QC tested).

Mouse CD40 Ligand, His,Flag Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.