Human Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc-pro), Unconjugated, Insect 500 ug

Produktübersicht

• Artikelname: Human Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc-pro), Unconjugated, Insect 500 ug
• Artikelnummer: ABS-CL2-H5589-500UG
• Hersteller Artikelnummer: CL2-H5589-500ug
• Alternativnummer: ABS-CL2-H5589-500UG
• Hersteller: AcroBiosystems
• Wirt: Insect
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on shortlived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 28.5 kDa
• Tag: N-10*His & C-Twin Strep
• NCBI: 56856
• Puffer: 20 mM HEPES, 150 mM NaCl, pH7.5
• Reinheit: 90%
• Formulierung: Liquid
• Target-Kategorie: Claudin-18.2

Bilder

Immobilized Human Claudin-18.2 Protein, His,Twin-Strep Tag (Cat. No. CL2-H5589) at 2 µg/mL (100 µL/well) can bind Anti-Claudin-18.2 Antibody with a linear range of 0.1-4 ng/mL (QC tested).