Biotinylated Human CD200 R1 / CRTR2 Protein, Fc,Avitag(TM)
Artikelnummer:
ABS-CR2-H82F4-25UG
Hersteller Artikelnummer:
CR2-H82F4-25ug
Alternativnummer:
ABS-CR2-H82F4-25UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Biotin
Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. This gene encodes a receptor for the OX2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulinlike domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptorsubstrate interaction may function as a myeloid downregulatory signal. CD200 and its receptor CD200R are both type1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergicreaction, autoimmune diseases, allograft, neurological diseases and other autoimmunerelated diseases. The interaction between CD200, which is mainly present in neurons but also in astrocytes, and CD200R1, which is mainly present in microglia, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions. Alterations in the expression of CD200 and CD200R1 have been described in neurodegenerative diseases, but little is known about the mechanism of regulation of these proteins under physiological or pathological conditions. - Proteine/Peptide
