Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin, Unconjugated, Human

Produktübersicht

• Artikelname: Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin, Unconjugated, Human
• Artikelnummer: ABS-CSR-M5256-1MG
• Hersteller Artikelnummer: CSR-M5256-1mg
• Alternativnummer: ABS-CSR-M5256-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Mouse
• Konjugation: Unconjugated

Produktbeschreibung

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colonystimulating factor receptor (MCSFR), CD115 Cluster of Differentiation 115 (CD115), CFMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimers disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 81.8 kDa
• Tag: C-Fc
• NCBI: 001032948
• Puffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: M-CSF R

Bilder

Immobilized Mouse M-CSF Protein at 2µg/mL (100 µL/well) can bind Mouse M-CSF R, Fc Tag (Cat. No. CSR-M5256) with a linear range of 0.3-12.8 ng/mL (Routinely tested).

Mouse M-CSF R, Fc Tag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.